ADDUCTS CHIMIQUES ET BIOCHIMIQUES DE BIOMARQUEURS DE L'EXPOSITION D'ORGANOPHATES

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专利权人:

HUMAN BIOMOLECULAR RESEARCH INSTITUTE

发明人:

CASHMAN, JOHN R.,MACDONALD, MARY T.

申请号：

CA2721422

公开号：

CA2721422C

申请日:

2009.04.14

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

The invention provides compounds of Formula (I):OP-Peptide-Linker-CP (I)whereinOP is selected from the group consisting of reactiveorganophosphorus reagents, nerve agents and pesticides, wherein P is Spstereoisomer, Rpstereoisomer, or mixture thereof；R and R' are as defined in the description；X is oxygen, sulfur, selenium or imino；Peptide is a sequence of amino acids containing a serine, threonine ortyrosineto which an OP is attached, wherein a total number of amino acids is between 7and 41；Linker is an amino acid or other bifunctional reagent capable of covalentlylinking OP-peptide to a CP；CP is a conjugate protein used to display haptens for antibody generation； andsalts thereof.

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