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Fusion polypeptides comprising mucin-domain polypeptide linkers
专利权人:
Alkermes; Inc.
发明人:
Alvarez, Juan,McSweeney, Leslie A.
申请号:
AU2013271541
公开号:
AU2013271541B2
申请日:
2013.06.06
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
The invention provides fusion proteins having improved bioactivity comprising a first polypeptide fusion partner and a second polypeptide fusion partner wherein the first fusion partner is linked to the second fusion partner by a mucin-domain polypeptide linker and wherein the bioactivity of the fusion protein of the invention is improved as compared to fusion of the first polypeptide fusion partner and the second polypeptide fusion partner in the absence of the mucin-domain polypeptide linker. Mucin-domain polypeptide linkers comprise a mucin domain that is rich in potential glycosylation sites, and has a high content of serine and/or threonine and proline, which can represent greater than 40% of the amino acids within the mucin domain and further comprise at least about 60% of its mass due to the glycans.
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中国工程科技知识中心
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