您的位置: 首页 > 农业专利 > 详情页

Compounds that modulate the activity of proteasomes
专利权人:
PROTEOSTASIS THERAPEUTICS; INC.
发明人:
MEGAN FOLEY,ROBERT K. CHAMBERS,BRADLEY TAIT
申请号:
ARP130100237
公开号:
AR089814A1
申请日:
2013.01.25
申请国别(地区):
AR
年份:
2014
代理人:
摘要:
1. Requirement 1: a formula compound (1) or a salt acceptable on drugs, solvato, Clara or prodroga, wherein Q1 and Q2 are independently selected from the nitrogen and Cr 8310 groups;A is sulfur, oxygen or no. 8311; 749191;R¹ and R² are independently selected from each other from the group consisting of hydrogen, optionally substituted C₁₋₁₀ alkyl, optionally substituted C₂₋₁₀ alkenyl, optionally substituted C₂₋₁₀ alkynyl, optionally substituted C₁₋₁₀ alkoxy, C₃₋₁₂ cycloalkyl optionally substituted, optionally substituted C₃₋₁₂ cycloalkenyl, optionally substituted heterocycle, optionally substituted aryl and optionally substituted heteroaryl; or alternatively,R1 and R2 are combined with nitrogen atoms to form an alternative heterocycle or alternative heteromorphism; X is selected from or3 group,C (O) RC (O) OROC (O) RC (o) No. 7491; r7495;C (o) No. 7491; s (o) 8322; R3,S (O) NR RS (o) No. 7491; r7495;No. 7491; s (o) 8322; R3,C, SR3,S (O) RS (O) RP (O) (OR)No. 7491; No. 74955;N (R) ORNo. 7491; C (o) C (o) R3,No. 7491; C (o) R3,NR C (O) NR R y NR S (O) NR RR³ is selected from the group consisting of hydrogen, optionally substituted C₁₋₁₀ alkyl, optionally substituted C₂₋₁₀ alkenyl, optionally substituted C₂₋₁₀ alkynyl, optionally substituted C₃₋₁₂ cycloalkyl, optionally substituted C₃₋₁₂ cycloalkenyl, optionally substituted heterocycle, optionally substituted aryl and optionally substituted heteroaryl; Rᵃ and Rᵇ are independently selected from each other from the group consisting of hydrogen, optionally substituted C₁₋₁₀ alkyl, optionally substituted C₂₋₁₀ alkenyl, optionally substituted C₂₋₁₀ alkynyl,e. Non selective replacement, selective replacement, optional replacement and irregular replacement; R74919 and r74955 are used together with nitrogen atoms and connected with them to form an alternative heteromorphic alternative or alternative heteromorphic alternative; e es C (r8308; 74919) (r8308; 74955);Each of the j1s,Uh...J3 and j830808 are independent C (r8309; 749
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充