FATHEREE, PAUL R.,VAN ORDEN, LORI JEAN,SMITH, CAMERON,BRANDT, GARY E. L.,SULLIVAN, STEVEN D. E.,KLEINSCHEK, MELANIE A.,CRATER, GLENN D.
申请号：
ARP180100542
公开号：
AR111241A1
申请日:
2018.03.08
申请国别(地区):
AR
年份:
2019
代理人:
摘要：
This compound or a pharmaceutically acceptable salt can be used as an inhibitor of pentachloromethane. It also provides pharmaceutical ingredients that contain these compounds, methods of using these compounds to treat processes and respiratory diseases, and useful intermediaries in the production of these compounds. 1. Requirement 1: a compound (1) with formula characteristics,where: R¹ is selected from hydrogen, C₁₋₃alkyl, and C₃₋₆cycloalkyl, and X is selected from -C (O) R² and -CH₂R¹⁶,O R1 is selected from - (ch.8322) 8322； - 830404； - R2 and 4-6 isomers containing one nitrogen atom, in which the nitrogen atom can be selectively replaced by R2,X was selected from - ch8322； Oran 3 and - C (o) or 83088；where R² is selected between -NR¹³R¹⁴ and -OR¹⁵；R¹³ and R¹⁴ taken together with the nitrogen atom to which they are attached form a 6 or 7-membered monocyclic or bicyclic heterocyclyl containing an additional nitrogen atom, where the additional nitrogen atom is substituted with R³ and the heterocyclyl is optionally substituted with one or two R⁴,O R3 and r183088 together with the nitrogen atoms attached to them form a 5-6-member isomer, in which - nr8309；； r8310 and r8311 are optional；O R1 3 and r83 080 form morphine alcohol together with the nitrogen atoms attached to them, or R1 33 is r831222 and R1 83088es r8313；R³ is selected from hydrogen, C₃₋₆cycloalkyl, and C₁₋₃alkyl, where C₁₋₃alkyl is optionally substituted with -OH or -OC₁₋₃alkyl； R⁴ is C₁₋₃alkyl, where C₁₋₃alkyl is optionally substituted with -OH； R⁵ and R⁶ are independently C₁₋₃alkyl or R⁵ and R⁶ taken together with the nitrogen atom to which they are attached form a 5 or 6 membered heterocyclyl that optionally includes an oxygen atom； R⁷ is C₁₋₃alkyl, optionally substituted with a 5- or 6-membered heterocyclyl containing a nitrogen atom； R⁸ is hydrogen or C₁₋₃alkyl；R8313es - (ch8322)； nr.8304；； isomerization compound of R1 or 4-6 members, in which there is a nitrogen atom, where the nitrogen atom is rep
