COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT OF THE SAME, PHARMACEUTICAL COMPOSITION, AND, USE OF A COMPOUND

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专利权人:

MERCK FROSST CANADA LTD.

发明人:

NICOLAS LACHANCE,CHUN SING LI,JEAN-PHILIPPE LECLERC,YEEMAN K. RAMTOHUL

申请号：

BRPI0719702

公开号：

BRPI0719702A2

申请日:

2007.11.28

申请国别(地区):

BR

年份:

2013

代理人:

摘要：

Azacycloalkane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis； obesity； diabetes； neurological disease； metabolic syndrome； insulin resistance； and liver steatosis.

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中国工程科技知识中心

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http://www.ckcest.cn/home/