University of Maryland, Baltimore;University of Pittsburgh - Of the Commonwealth System of Higher Education
发明人:
Nicolas Paul Sluis-Cremer,Adam Daniel Tomich,Yohei Doi,Eric J. Sundberg,Erik H. Klontz,Steven Fletcher
申请号：
US16476845
公开号：
US20190358232A1
申请日:
2018.01.11
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Compounds, pharmaceutical compositions, and methods for reversing fosfomycin resistance are disclosed. Embodiments of the disclosed compounds inhibit fosfomycin-inhibiting enzymes. Some embodiments of the compounds are FosA inhibitors. The disclosed pharmaceutical compositions include (i) fosfomycin or a pharmaceutically acceptable salt thereof and (ii) a compound, or a pharmaceutically acceptable salt thereof, which inhibits a fosfomycin-inhibiting enzyme. A method of inhibiting growth of a fosfomycin-resistant bacterium includes contacting the bacterium with (i) fosfomycin or a pharmaceutically acceptable salt thereof and (ii) an effective amount of a disclosed compound or a pharmaceutically acceptable salt thereof.
