The present invention relates to a method to predict the risk of obtaining a stress related mood disorder or syndrome by a person, comprisinga. Measuring at least three parameters comprising at least one sympathetic, one parasympathetic and one hormonal parameter during a stress response, said result of the measurement depicted as Rs, Rp and Rh respectivelyb. Estimate the value of one of these parameters by calculating it from the other two parametersc. Predict the risk on basis of the deviation between calculated and measured value of the parameter that has been estimated in step b).