Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents

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专利权人:

Moshe Laudon;Tal Peleg-Shulman;Dvorah Daily

发明人:

Tal Peleg-Shulman,Moshe Laudon,Dvorah Daily

申请号：

US13197462

公开号：

US08236858B2

申请日:

2011.08.03

申请国别(地区):

US

年份:

2012

代理人:

摘要：

This invention is directed to substituted aryl compounds, which are linked to a substituted indole moiety by various linkers, and the kynurenine/kynuramine-like metabolites of these agents, their preparation and pharmaceutical compositions containing these compounds. This invention further is directed to the pharmaceutical use of the compounds for inhibiting GSK3β kinase and/or modulating N-methyl-D-aspartate (NMDA) channel activities for the treatment of neurodegenerative and other disorders.

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中国工程科技知识中心

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http://www.ckcest.cn/home/