This invention is directed to substituted aryl compounds, which are linked to a substituted indole moiety by various linkers, and the kynurenine/kynuramine-like metabolites of these agents, their preparation and pharmaceutical compositions containing these compounds. This invention further is directed to the pharmaceutical use of the compounds for inhibiting GSK3β kinase and/or modulating N-methyl-D-aspartate (NMDA) channel activities for the treatment of neurodegenerative and other disorders.本發明係針對藉由各種鍵連基連接於經取代吲哚部分的經取代芳基化合物及該等藥劑之犬尿胺酸/類犬尿胺代謝物、其製備及含有該等化合物之醫藥組合物。本發明進一步係針對該等化合物用於抑制GSK3β激酶及/或調節N－甲基－D－天冬胺酸(NMDA)通道活性以便治療神經退化性病症及其他病症的醫藥用途。
