The present invention is directed to substituted pyridine derivatives, pharmaceutical compositions containing said derivatives and the use of said derivatives in the treatment of disorders mediated by c-fms kinase. The present invention is further directed to a process for the preparation of said substituted pyridine derivatives.La presente invención está dirigida a derivados de piridina sustituidos, composiciones farmacéuticas que contienen dichos derivados y el uso de dichos derivados en el tratamiento de trastornos mediados por la c-fms quinasa la presente invención se refiere, además, a un proceso para la preparación de dichos derivados de piridina sustituidos.