Compositions and methods for modulation of vasculature and / or function

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专利权人:

テクノロジーズ，インコーポレーテッド;マリン;マリン ポリマー テクノロジーズ,インコーポレーテッド;ポリマー

发明人:

ヴォウルナキス，ジョン，エヌ．,フィンケイルステイン，セルジオ,ヴォウルナキス,ジョン,エヌ.,フィンケイルステイン,セルジオ

申请号：

JP2010151827

公开号：

JP5543861B2

申请日:

2010.07.02

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

The present invention relates to compositions comprising semi-crystalline ²-1-4-N-acetylglucosamine polymers (p-GlcNac) and methods utilizing such polymers modulation of vascular structure and/or function. The compositions and methods disclosed are useful for stimulating, in a p-GlcNac concentration-dependent manner, endothelin-1 release, vasoconstriction, and/or reduction in blood flow out of a breached vessel, as well as for contributing to or effecting cessation of bleeding. The methods of the present invention comprise topical administration of materials comprising semi-crystalline p-GlcNac polymers that are free of proteins, and substantially free of single amino acids as well as other organic and inorganic contaminants, and whose constituent monosaccharide sugars are attached in a ²-1-4 conformation.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/