A method for pressure-assisted irreversible electroporation of tissue cells, including placing one or more electrodes (14) near tissue cells to be treated, positioning a pressure source (16) operable to apply pressure pulses to the tissue cells, and applying to the tissue cells a combination of electrical pulses through the one or more electrodes (14) and pressure pulses from the pressure source (16) such that the combination is sufficient to induce irreversible electroporation of the tissue cells, and wherein the electrical pulses without the pressure pulses are insufficient to induce irreversible electroporation of the tissue cells.
