UTILISATION D'UN POLYPEPTIDE POUR ACCOMPLIR UNE SIGNALISATION IMMUNITAIRE ET/OU INFLUENCER LA FONCTION DE BARRIERE INTESTINALE ET/OU MODULER UN ETAT METABOLIQUE
WAGENINGEN UNIVERSITEIT;UNIVERSITE CATHOLIQUE DE LOUVAIN
发明人:
BELZER, CLARA,DE VOS, WILLEM MEINDERT,CANI, PATRICE DANIEL
申请号:
CA2984985
公开号:
CA2984985A1
申请日:
2016.05.04
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
It has been found that an extracellular polypeptide derived from Akkermansia municiphila is capable of modulating and/or promoting gut mucosal immune system function and/or maintaining and/or restoring metabolic status and/or increasing the physical integrity of the gut mucosal barrier in a mammal. The polypeptide or host cells comprising such polypeptide may be employed to prevent and/or treat a variety of conditions that benefit from an increased physical integrity of the gut mucosal barrier and/or an improved gut mucosal immune system function and metabolic status.