The invention relates to a milk bottle sterilization device. The device comprises a frame, a top cover, a base and a sterilization support, wherein a heating cavity for accommodating a milk bottle is formed by the frame and the top cover an electric heating component and a temperature sensor are arranged at the bottom of the frame a switch and a power supply indicating lamp are arranged on the frame a control circuit board is arranged in the frame the electric heating component, the temperature sensor, the switch and the power supply indicating lamp are respectively electrically connected with the control circuit board a sensing component is arranged in the frame, and is electrically connected with the control circuit board when the sensing component senses that the sterilization support is put into the frame, the control circuit board is used for switching the mode of the milk bottle sterilization device from milk bottle heating insulation to milk bottle sterilization. The milk bottle sterilization device can be used for heating and insulating a milk bottle and sterilizing the milk bottle with steam, can realize automatic switching between the milk bottle heating insulating mode and the milk bottle sterilization mode, and is very convenient to use.