This invention is directed to a moxibustion therapy device and its use. The moxibustion therapy device comprises a housing, an integrated electric circuit board inside the housing, a power supply module, and a heating module. A protruding portion on one side of the housing is covered with a metal mesh cover. The integrated electric circuit board, the power supply module, and the heating module are connected to one another. The heating module is tightly pressed against one side of the metal mesh cover. Users can use the moxibustion therapy device at anytime anywhere without others assistance. The moxibustion therapy device can help people expel cold and dampness and relieve pain.