The present invention provides a pharmaceutical preparation that is a combination pharmaceutical preparation for inducing a specific immune response to an antigenic peptide, wherein: the pharmaceutical preparation comprises (I) the antigenic peptide and (II) an expression vector that encodes a chimera hepatitis B virus core antigen polypeptide to which the antigenic peptide has been inserted or added, the antigenic peptide being inserted into the region of amino acid residues 74 to 87 or 130 to 138 of the hepatitis B virus core antigen polypeptide or added to the N terminal or C terminal of the hepatitis B virus core antigen polypeptide； and the antigenic peptide (I) and the expression vector (II) are given substantially simultaneously to an application subject.
