The present invention provides uses of an Ascophyllum nodosum extract for manufacture of composition for regulating expression of a gene group, wherein the gene group includes a Group A gene selected from the group consisting of TGM1, KRT14, FLG, AQP3, GBA, HAS3, and combinations thereof, and a Group B gene selected from the group consisting of HAS2, MMP2, LOX, and combinations thereof. The Ascophyllum nodosum extract improves skin moisture, skin elasticity, and resistance to ultraviolet radiation.本發明提供一種泡葉藻萃取物用於製備調節一基因群組表現之組合物之用途，其中，該基因群組包含一選自由轉麩胺酸醯胺基酶(TGM1)、角質蛋白14(KRT14)、絲聚蛋白(FLG)、水通道蛋白3(AQP3)、β葡萄糖腦苷酯酶(GBA)、玻尿酸合成酶3(HAS3)、及其任意組合所組成群組之A群基因，及一選自由玻尿酸合成酶2(HAS2)、基質金屬蛋白酶2(MMP2)、賴胺醯氧化酶(LOX)、及其任意組合所組成群組之B群基因。該泡葉藻萃取物透過調節上述基因群組表現而提升皮膚含水量與彈性及對紫外線的抵抗力。
