[Problem to be solved] To provide a transgenic (TG) non-human mammal expressing human matrix metalloproteinase 2 (hMMP2) in whole body tissues, and a model animal developing COPD.[Solution] The objective is solved by development of an hMMP2-expressing TG non-human mammal characterized by the inclusion of a promoter to induce gene expression, and by the expression of the whole hMMP2 gene region placed on the downstream of the promoter that can induce systemic expression of the gene. The promoter for gene expression is preferably abeta-actin promoter, and the non-human mammal is preferably a mouse. Chronic obstructive pulmonary disease (COPD) can be induced by exposing the TG non-human mammal to inhalation of cigarette smoke extract.
