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PHARMACEUTICAL COMPOSITIONS, INCLUDING AMINOCYCLOHEXANE DERIVATIVES
专利权人:
МЕРЦ ФАРМА ГМБХ УНД КО. КГАА (DE)
发明人:
ПЛИТТ Кирстен (DE),ПУРМАНН Бригитте (DE),СЦЛАК-ФРАЙЕР Альда (DE),ХАУПТМАЙЕР Бернхард (DE)
申请号:
RU2011102784/15
公开号:
RU2011102784A
申请日:
2009.06.25
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. A composition comprising a compound selected from compounds of formula (I)! (I)! where R * is - (CH2) n- (CR6R7) m-NR8R9! where n + m = 0, 1 or 2! where R1-R7 are independently selected from the group consisting of hydrogen and C1-6 alkyl, where R8 and R9 are independently selected from the group consisting of hydrogen and C1-6 alkyl, or where together they represent lower alkylene- (CH2) x-, where x takes values from 2 to 5, inclusive, and its optical isomers, enantiomers, hydrates, solvates, polymorphs and pharmaceutically acceptable salts; ! and a pharmaceutically acceptable cyclodextrin or a combination of pharmaceutically acceptable cyclodextrins. ! 2. The composition according to claim 1, where the composition is an aqueous liquid composition. ! 3. The composition according to claim 1, where the composition is a semi-solid composition. ! 4. The composition according to claim 1, where the composition is a solid composition. ! 5. The composition according to claim 1, where the specified pharmaceutically acceptable cyclodextrin is selected from alpha-cyclodextrin, beta-cyclodextrin, randomly methylated beta-cyclodextrin, 2-O-methyl-beta-cyclodextrin, heptakis- (2,6-di-O- methyl) -beta-cyclodextrin (dimethyl-beta-cyclodextrin), acetylated dimethyl-beta-cyclodextrin, heptakis- (2,3,6-tri-O-methyl) -beta-cyclodextrin (trimethyl-beta-cyclodextrin), 2- hydroxypropyl beta-cyclodextrin, sulfoalkyl ether-beta-cyclodextrin, sulfobutyl ether-beta-cyclodextrin, O-carbox methyl-O-ethyl-beta-cyclodextrin, glucuronyl-glucosyl-beta-cyclodextrin, glucosyl-beta-cyclodextrin, maltosyl-beta-cyclodextrin, beta-cyclodextrin sulfate, beta-cyclodextrin phosphate, gamma-cyclodextrin, 2-hydroxypropyl-gamma cyclodextrin, sulfo1. Композиция, включающая соединение, выбранное из соединений формулы (I) ! (I) ! где R* обозначает -(CH2)n-(CR6R7)m-NR8R9 ! где n+m=0, 1 или 2 ! где R1-R7 независимо выбраны из группы, состоящей из водорода и C1-6алкила, где R8 и R9 независ
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