КАЙЗЕР Патрик Ф. (US),ДЖОНСОН Тодд Джозеф (US),КЛАРК Джастин Томас (US),ШЕЛКЕ Намдев (US),РАСТОГИ Рачна (US)
申请号：
RU2014106067/14
公开号：
RU2014106067A
申请日:
2012.07.20
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. An intravaginal device containing a reservoir of one or more vaginally applicable drugs, characterized in that the reservoir is surrounded at least partially by a hydrophilic elastomer. The device according to claim 1, characterized in that the hydrophilic elastomer has the ability to swell. The device according to claim 1, characterized in that the hydrophilic elastomer swells from about 20% to about 100% of the mass. The device according to claim 1, characterized in that the hydrophilic elastomer is a multiblock poly (urethane ether) or silicone poly (urethane ether). The device according to claim 1, characterized in that the poly (urethane ether) is swellable in water and includes poly (ethylene oxide) .6. The device according to claim 1, characterized in that the poly (urethane ether) is TecophilicHP-60D-20, HP-60D-35, HP-60D-60 or HP-93A-100 or HydroThane80A or 93A.7. The device according to claim 1, further comprising a non-swellable elastomer. The apparatus of claim 1, further comprising a poly (urethane ether) selected from TecoflexEG-80A, TecoflexEG-85A or TecoflexEG-93A or ChronoThaneT75A, T75B, T75C or T75D polyurethane. The device according to claim 1, characterized in that the reservoir holds a liquid, solid or semi-solid composition containing one or more intravaginally applicable agents. The device according to claim 1, characterized in that the reservoir is filled with a solid drug-containing polymer. The device according to claim 1, characterized in that the drug is a macromolecule or a hydrophilic small molecule. The device according to claim 1, characterized in that the drug is a peptide, protein or polysaccharide. The device according to claim 1, characterized in that the drug is selected1. Интравагинальное устройство, содержащее резервуар одного или более вагинально применимых лекарственных средств, отличающееся тем, что резервуар окружен, по меньшей мере, частично гидрофильным эластомером.2. Устройство по п. 1, отличающееся тем, что гидрофил
