A compound represented by the general formula (I) or a pharmacologically acceptable salt thereof has an excellent LCAT-activating effect and is useful as an active ingredient in a therapeutic or prophylactic agent for arteriosclerosis, arteriosclerotic heart disease, coronary heart disease (including heart failure, myocardial infarction, angina pectoris, cardiac ischemia, cardiovascular disturbance, and restenosis caused by angiogenesis), cerebrovascular disease (including stroke and cerebral infarction), peripheral vascular disease (including diabetic vascular complications), dyslipidemia, hypo-HDL-cholesterolemia, hyper-LDL-cholesterolemia, or renal disease, particularly, an anti-arteriosclerotic agent, wherein R is an optionally substituted aryl group or an optionally substituted heteroaryl group, and R 1 is a hydrogen atom or a hydroxy group.一種以通式(I)所示之化合物、或其藥理容許鹽，其係具有優異的LCAT活化作用，且可用於作為動脈硬化症、動脈硬化性心臟病、冠狀動脈性心臟病(包含心臟衰竭、心肌梗塞、心絞痛、心臟缺血、心血管障礙及血管形成性再狹窄)、腦血管疾病(包含腦中風及腦梗塞)、末梢血管疾病(包含糖尿病血管合併症)、異常血脂症、低HDL膽固醇血症、高LDL膽固醇血症、或腎疾病之治療劑或預防劑，特別是抗動脈硬化劑之有效成分。[式中，R為可經取代之芳基或可經取代之雜芳基；R1為氫原子或羥基。]
