Disclosed is a therapeutic management method of hypercholesterolemia in mammals. More specifically, the present invention relates to a method of reducing high levels of circulating cholesterol (hypercholesterolemia) in the blood stream of mammals, said method involving step of administering therapeutically effective amounts of Calebin A to said mammals to bring about the effects of (i) reducing the amount of total blood cholesterol levels； (ii) reducing the concentrations of low density lipoproteins (LDL) and very low density lipoproteins (VLDL)； (iii) increasing the concentrations of high density lipoproteins (HDL) and (iv) reducing concentrations of serum triglycerides.在此揭示一種哺乳動物之高膽固醇血症之治療管理方法。更確切地，本發明有關一種降低哺乳動物之血流中，高位準的循環膽固醇(高膽固醇血症)之方法，該方法涉及投與一治療上有效量之卡萊賓A(Calebin A)至該哺乳動物之步驟，以便帶來有關下列之效果：(i)降低總血液膽固醇位準之數量；(ii)降低低密度脂蛋白(LDL)以及超低密度脂蛋白(VLDL)之濃度；(iii)增加高密度脂蛋白(HDL)之濃度，以及(iv)降低血清三酸甘油酯之濃度。
