The present invention refers to a composition and a device comprising whole blood cells for treating cholesterol disorders for use in a method comprising administering at least one treatment regime including two or more rounds of plasmapheresis to a patient having abnormal total cholesterol, abnormal LDL levels and/or abnormal HDL levels prior to treatment. Treatment with said composition and device results in decreased LDL levels in patients having abnormal LDL levels and increased HDL levels in patients having abnormal HDL levels. Each subsequent round of plasmapheresis is conducted weekly, but no more than twice per week.本發明有關於一種用以治療膽固醇疾病之包含全血細胞的組成物及裝置，其用於包含下列的方法中：對在治療前帶有異常總膽固醇、異常LDL濃度及/或異常HDL濃度的患者施予包括兩回或更多回血漿清除術的至少一治療方案。使用該組成物以及裝置的治療在帶有異常LDL濃度的患者中使LDL濃度降低，而在帶有異常HDL濃度的患者中使HDL濃度增加。各後續回合的血漿清除術是每週進行，但每週不超過兩次。
