Bobby N. Trawick,David W. Berberich,Christopher W. Grote
申请号：
US15255979
公开号：
US10604488B2
申请日:
2016.09.02
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides (+)-morphinans comprising Toll-like receptor 9 (TLR9) antagonist activity, as well as methods for using the (+)-morphinans to treat pain. Also provided are pharmaceutical combination compositions comprising a (+)-morphinan and an opioid agonist/monoamine reuptake inhibitor, as well as methods for using the combination compositions to treat pain.
