(+)-MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF

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专利权人:

Mallinckrodt LLC

发明人:

Bobby N. Trawick

申请号：

US16779796

公开号：

US20200172488A1

申请日:

2020.02.03

申请国别(地区):

US

年份:

2020

代理人:

摘要：

The present invention provides (+)-morphinans comprising Toll-like receptor 9 (TLR9) antagonist activity, as well as methods for using the (+)-morphinans to treat pain. Also provided are pharmaceutical combination compositions comprising a (+)-morphinan and an opioid agonist/monoamine reuptake inhibitor, as well as methods for using the combination compositions to treat pain.

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