Provided is a method for preventing and/or treating lipid-induced renal injury and related diseases thereof of a subject, comprising administering a preventively and/or therapeutically effective amount of plasminogen to a subject prone to suffer or suffering lipid metabolism disorders, or suffering other diseases accompanied by lipid metabolism disorders. The present invention also relates to a medicine, pharmaceutical composition, product, and kit comprising plasminogen and used for preventing and/or treating lipid-induced renal injury and related diseases thereof of a subject.本發明涉及預防和/或治療受試者脂質腎損傷及其相關病症的方法,包括給藥受試者預防和/或治療有效量的纖溶酶原,其中所述受試者易患脂肪代謝紊亂、患有脂肪代謝紊亂或罹患其它疾病並伴有脂質腎損傷。本發明還涉及用於預防和/或治療受試者脂質腎損傷及其相關病症的包含纖溶酶原的藥物、藥物組合物、製品、試劑盒。