METHOD FOR PRODUCING COMPREHENSIVE ANTI-SURFACE ANTIBODY WHEREIN THE ANTIGEN USED IS A MICROORGANISM FIXED BY A PROTEIN CROSSLINKING AND FIXATION REAGENT
A method for preparing comprehensive antibodies against whole proteins that are expressed on the surface of a microorganism and the comprehensive antibodies obtained by the method are provided. The method for preparing comprehensive antibodies against whole proteins that are expressed on the surface of a microorganism comprises: (a) treating a microorganism with a protein crosslinking and immobilization reagent and thus immobilizing proteins expressed on the surface of the microorganism via intramolecular crosslinking (b) administering the microorganism as an immunogen immobilized using the protein crosslinking and immobilization reagent to an animal and (c) obtaining antibodies from the animal.
