METHOD FOR PREPARING COMPREHENSIVE ANTI-SURFACE ANTIBODY USING MICROORGANISM IMMOBILIZED AS ANTIGEN WITH PROTEIN CROSSLINKING AND IMMOBILIZATION REAGENT
Masayoshi Shichiri,Yasuhiro Ii,Ikuko Ii,Kentaro Ii,Daisuke Ii,Maiko Ii
申请号：
US13141009
公开号：
US20120164135A1
申请日:
2009.12.18
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A method for preparing comprehensive antibodies against whole proteins that are expressed on the surface of a microorganism and the comprehensive antibodies obtained by the method are provided. The method for preparing comprehensive antibodies against whole proteins that are expressed on the surface of a microorganism comprises:(a) treating a microorganism with a protein crosslinking and immobilization reagent and thus immobilizing proteins expressed on the surface of the microorganism via intramolecular crosslinking(b) administering the microorganism as an immunogen immobilized using the protein crosslinking and immobilization reagent to an animal and(c) obtaining antibodies from the animal.
