Disclosed is a therapeutic agent for psoriasis or atopic dermatitis, which comprises an anti- antibody as an active ingredient.Specifically disclosed is a therapeutic agent for psoriasis or atopic dermatitis, which comprises, as an active ingredient, a comprehensive anti- surface antibody including an antibody against the entire of a protein molecule that is expressed on the surface of and is produced through the steps of: (a) treating cells with a protein-crosslinking/immobilizing reagent to immobilize a protein expressed on the surfaces of the cells by means of intermolecular crosslinking； (b) administering the cells that have been immobilized with the protein-crosslinking/immobilizing reagent to an animal as an immunogen； and (c) obtaining the antibody from the animal.
