Ocular iontophoresis device and method for delivering any ionized drug solution to the cornea includes: a reservoir containing a solution suitable to be positioned on the eye an active electrode disposed in or on the reservoir and a passive electrode suitable to be placed on the skin of the subject, elsewhere on the body elements for irradiating the cornea surface with suitable light for obtaining corneal cross-linking after the drug delivery wherein the reservoir and the active electrode are transparent to UV light and/or visible light and/or IR light. The method includes: positioning the iontophoretic device on the eye to be treated driving the solution by a cathodic current applied for 0.5 to 5 min, at an intensity not higher than 2 mA and thereafter irradiating, with UV light for 5 to 30 min at a power of 3 to 30 mW/cm2 thereby obtaining the corneal cross-linking of the solution.
