Claim 1: A combination characterized in that it comprises a compound of formula (1) or a pharmaceutically acceptable salt thereof, wherein: each of R¹ and R² is independently hydrogen, C₁₋₇-alkyl or C₃₋₁₀-carbocycle,with the proviso that R¹ and R² are not both hydrogen； R³ is a 5-11 membered heteroaryl ring containing one to three heteroatoms selected from nitrogen, oxygen, and sulfur, where the heteroaryl ring is optionally independently substituted with one to three groups selected from C₁₋₅ alkyl optionally substituted with one to three halogen atoms, C₁₋₅ alkoxy,C₁₋₃ hydroxy,a. Halogen, hydrogen xi-o-bencilo, oxo, cyanogen, amino-nh-carbocyclo c83231；C₁₋₆ alkylamino and C₁₋₃ dialkylamino；R83088 is hydrogen, c832131 coking；d. Keywords halogen or nitrogen； r83096c8321c831832626；carbocycle C₃₋₁₀,Unorthodox period of 3-11 members, arilo, unorthodox period of 5-11 members, - C (o) - r8310,hydroxy or -NR⁷R⁸,a. Each r83099 can be replaced by one to three groups selected from r8313；R1.83044 and R1；R⁶ is C₃₋₈ heterocycle or -NH-5-6 membered heterocycle, each optionally independently substituted with one to three groups selected from R⁹,R1.83044 and R1；e. Each r831181 and r831222 of r831181 and r831222 is a separate hydrogen, which is replaced by c8332121 tar as a 5-6 substitute；C₃₋₁₀ carbocycle optionally substituted with hydroxy or C₁₋₆ alkyl；R8313,R83041 and R1 are independent from (a) - (H), (b) - (H), (c) halogen (d) - CN, (E) - cf8323；(f) C83216c83318326 is replaced by one to three-oh-n (R 2) (r 13)；3-6 membered heterocycle, C₁₋₆ alkoxy,C₁₋₆-O-alkoxy-C₁₋₆-alkyl,-CO₂R¹²,-C (o) n (R 2) (r 13) O-S (o) 8345； - c83231 asphalt；(G) alcoxi C(H) -N (R) (R)(I) -S (O) -alquilo C(J) -CO R(K) -C (O) N (R) (R)(L) -S (O) N (R) (R)(m) a 3-10 membered heterocyclic group optionally substituted with one to three C₁₋₆ alkyl groups,(n) Oxo, (o) - C (o) - asphalt c832131；R¹² and R¹³ are each independently selected from -H, -C₁₋₆alkyl,C O q Cand a 3-6 membered heterocyclic group, each of
