THROSBY, MARK,索罗斯比 马克,索羅斯比 馬克,FRIESEN, ROBERT H. E.,佛瑞森 罗伯特H E,佛瑞森 羅伯特H E,KWAKS, THEODORUS H. J.,卡瓦克斯 席德罗斯H J,卡瓦克斯 席德羅斯H J,JONGENEELEN, MANDY A. C.,强吉尼伦 曼帝A C,強吉尼倫 曼帝A C
申请号：
TW099114829
公开号：
TWI589300B
申请日:
2010.05.10
申请国别(地区):
TW
年份:
2017
代理人:
摘要：
The present invention relates to binding molecules, such as human monoclonal antibodies, that bind to influenza virus comprising HA of the H3 subtype, such as H3N2, and have a broad neutralizing activity against such influenza virus. The disclosure provides nucleic acid molecules encoding the antibodies, their sequences and compositions comprising the antibodies and methods of identifying or producing the antibodies. The antibodies can be used in the diagnosis, prophylaxis and/or treatment of an influenza virus H3N2 infection. In a preferred embodiment, the antibodies provide cross-subtype protection, such that infections with H3, H7, and/or H10-based influenza subtypes can be prevented and/or treated.本發明係關於結合分子,諸如人類單株抗體,其結合至包含H3亞型之HA之流感病毒(諸如H3N2),且對該流感病毒具有廣泛中和活性。本案提供編碼該等抗體之核酸分子,其序列,及包含該等抗體之組合物,以及鑑別或產生該等抗體之方法。該等抗體可用於診斷、預防及/或治療流感病毒H3N2感染。在一項較佳實施例中,該等抗體提供交叉亞型保護,以便可預防及/或治療基於H3、H7及/或H10之流感亞型引起之感染。(無元件符號說明)
