Throsby, Mark,Friesen, Robert Heinz Edward,Kwaks, Theodorus Hendrikus Jacobus,Jongeneelen, Mandy Antonia Catharina
申请号：
AU2010247530
公开号：
AU2010247530B2
申请日:
2010.05.06
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
The present invention relates to binding molecules, such as human monoclonal antibodies, that bind to influenza virus comprising HA of the H3 subtype, such as H3N2, and have a broad neutralizing activity against such influenza virus. The disclosure provides nucleic acid molecules encoding the antibodies, their sequences and compositions comprising the antibodies and methods of identifying or producing the antibodies. The antibodies can be used in the diagnosis, prophylaxis and/or treatment of an influenza virus H3N2 infection. In a preferred embodiment, the antibodies provide cross-subtype protection, such that infections with H3, H7, and/or H10-based influenza subtypes can be prevented and/or treated.
