This invention provides a protein that is an enzyme that can be used for the enzyme replacement therapy of Fabrys disease, which has no allergic side effect, has high stability in blood, and is taken easily into the cell of the trouble internal organs, and the said protein has the activity of α-galactosidase. The protein of this invention is a protein obtained by converting the structure of active site of wild type human α-N-acetylgalactosaminidase to acquire the activity of α-galactosidase.本發明係提供一種蛋白質,其為能用於法布里病之酵素補充療法的酵素,無過敏性副作用,血中安定性高,對障礙臟器之細胞攝取容易,且具有α-半乳糖苷酸酶活性之蛋白質。本發明之蛋白質,係轉化野生型人類α-N-乙醯基氨基半乳糖酶之活性部位之構造而獲得α-半乳糖苷酸酶活性的蛋白質。
