Quinazoline analogs as receptor tyrosine kinase inhibitors农业专利-农业专业知识服务系统

发明人:: 埃利．华莱士,埃利．華萊士,乔治．托帕洛夫,喬治．托帕洛夫,约瑟夫．雷西卡托斯,約瑟夫．雷西卡托斯,亚历山大．巴克梅尔特,亞歷山大．巴克梅爾特,赵千,趙千,埃利.华莱士,埃利.華萊士,乔治.托帕洛夫,喬治.托帕洛夫,约瑟夫.雷西卡托斯,約瑟夫.雷西卡托斯,亚历山大.巴克梅尔特,亞歷山大.巴克梅爾特

摘要：: Under the bright offer of this Hair formula (I) indicate quinazoline Class like object: wherein 5,6,7 or 8 carbon of A With Twin Ring an at least Ge Knot close, And and in it Ring by most Two Ge Independence stand R3 base Mission replace. The bright It of this Hair includes using compound shown in formula (I) as I Xing Shou Body tyrosine kinase to inhibit Elixirs and with the method for what Zhi Treatment Over degree proliferative disease such as cancer.本發明提供下式(I)表示的喹唑啉類似物：其中A與雙環的5、6、7或8位碳的至少一個結合，並且其中環被最多兩個獨立的R3基團取代。本發明還包括使用式(I)所示化合物作爲I型受體酪氨酸激酶抑制劑和用於治療過度增生性疾病如癌症的方法。