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2-AMINO-2-PHENYLALKANOL DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
专利权人:
OROXCELL
发明人:
DENIS, ALEXIS,Дени Алексис,PACHOT, JEAN,Пашо Жан,DINI, CHRISTOPHE,Дини Кристоф
申请号:
UA2010010576
公开号:
UA101013C2
申请日:
2009.01.30
申请国别(地区):
UA
年份:
2013
代理人:
摘要:
Esters derived from 2-amino-2-phenylalkanol of general formula (I) in which: Ris H, straight or branched C1 to C4 alkyl, straight or branched C2 to C4 alkyl substituted by OH, alkoxy, alkylthio, acyloxy, NH, alkylamino, dialkylamino, alkylcarbamoyloxy, alkoxycarbonylamino, ureido or alkylureido, Ris a -CO-R radical in which R is H, alkyl, aryl, heterocyclyl, benzyl or heterocyclylmethyl, or else Ris a -CO-Y-Rradical for which Y is -O-, -S-, -NH-, or -Nalk- for which alk is straight or branched (C1 to C4) alkyl, and Ris alkyl, aryl, aralkyl or heterocyclylalkyl, which may be substituted by one or more halogen atoms or OH radicals, straight or branched (C1 to C4) alkyl radicals, or straight or branched (C1 to C4) alkoxy, alkylthio, acylaminoalkylthio, alkoxycarbonyl or acylamino radicals, or oxo radicals, or which may be substituted by RCOO- in which Ris an alkyl optionally substituted by benzyloxycarbonylamino, acylamino or by the residue of an amino acid, or represents a heterocycle, or else Ris a (C2 to C4) alkyl substituted by OH, alkoxy, alkylthio, acyloxy, NH, alkylamino, dialkylamino optionally forming, with the nitrogen atom to which they are attached, a 5-or 6-membered heterocycle optionally bearing another heteroatom (O or N), or substituted by alkylcarbamoyloxy, alkoxycarbonylamino, ureido or alkylureido, it being understood that said straight or branched substituted alkyl radical comprises at least C2 between >N-Rand the substituent and Ris a straight or branched (C1 to C4) alkyl unless specifically mentioned, alkyl or acyl are straight or branched (C1 to C7), in their R or S forms or mixtures thereof, and also the pharmaceutically acceptable salts thereof when they exist.Винахід стосується похідних складного ефіру 2-аміно-2-фенілалканолу загальної формули (І), у якій: Rявляє собою Н, лінійний або розгалужений алкіл, що містить від 1 до 4С, лінійний або розгалужений алкіл, що містить від 2 до 4С, заміщений ОН, алкокси, алкілтіо, ацилокси, NH, алкіламіно, д
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