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APPLICATION OF LACTOFERRINE-CONTAINING NUTRITIONAL COMPOSITIONS FOR STIMULATION OF IMMUNE CELLS
专利权人:
ЭмДжейЭн Ю. Эс. Холдингс ЛЛК (US)
发明人:
УИТТКЕ Аня (US),МУНОЗ Сесилия (US),БАНАВАРА Даттатрея (US)
申请号:
RU2013134129/15
公开号:
RU2013134129A
申请日:
2011.12.14
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A method of stimulating at least one type of a cell of innate immunity in a person, comprising administering to the person a nutritional composition comprising: a) a source of fat or lipids; b) a source of proteins; c) lactoferrin produced by a source other than the human body, wherein lactoferrin is characterized by at least 48% homology with the amino acid sequence AVGEQELRKCNQWSGL in the HLf fragment (349-364), so that the introduction of the nutritional composition stimulates at least one innate immune cell selected from the group consisting of macrophages, neutrophils, dendritic cells and their combinations. 2. The method of claim 1, wherein the nutritional composition is administered to an infant or child. The method of claim 1, wherein the source of fat or lipid is present at a level of from about 3 g / 100 kcal to about 7 g / 100 kcal. The method of claim 1, wherein the protein source is present at a level of from about 1 g / 100 kcal to about 5 g / 100 kcal. The method of claim 1, wherein the lactoferrin is present at a level of at least about 10 mg / 100 kcal. The method of claim 5, wherein the lactoferrin is present at a level of from about 70 mg / 100 kcal to about 220 mg / 100 kcal. The method of claim 1, wherein the lactoferrin is selected from the group consisting of lactoferrin other than human lactoferrin produced by a genetically modified human lactoferrin organism and combinations thereof. The method of claim 1, wherein the lactoferrin is stable and active under conditions in which human lactoferrin becomes unstable or inactive. The method of claim 8, wherein the nutritional composition was pasteurized1. Способ стимулирования у человека по меньшей мере одного типа клетки врожденного иммунитета, включающий введение человеку питательной композиции, содержащей:a) источник жиров или липидов;b) источник белков; иc) лактоферрин, произведенный отличным от человеческого организма источником, при этом лактоферрин характеризуется по меньшей мере 48% гомо
来源网站:
中国工程科技知识中心
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