The present invention relates to a mixture of Aspergillus flavus compound, folic acid, 5-fluoride (5-FU) and illinutecano, which are therapeutic methods for the treatment of colon tomato (CRC), especially for the metabolism of colon tomato (CRC).LA PRESENTE INVENCIÓN SE REFIERE A COMBINACIONES DE AFLIBERCEPT, ÁCIDO FOLÍNICO, 5-FLUOROURACILO (5-FU) E IRINOTECANO QUE SON TERAPÉUTICAMENTE ÚTILES PARA EL TRATAMIENTO DEL CÁNCER COLORRECTAL (CRC) Y EN PARTICULAR DEL CÁNCER COLORRECTAL (CRC) METASTÁSICO