A Pharmaceutical composition comprising aflibercept, folinic acid, 5-fluorouracil (5-fu) and irinotecan (FOLFIRI), each in a pharmaceutically effective amount. This combination is useful for the treatment of Colorectal Cancer (CRC) and, in particular, metastatic colorectal cancer (CRC)Una composicion farmaceutica que comprende aflibercept, acido folinico, 5-fluorouracilo (5-FU) e irinotecano (FOLFIRI), cada uno, en una cantidad farmaceuticamente eficaz. Dicha combinacion es util para el tratamiento de cancer colorrectal (CRC) y en particular cancer colorrectal (CRC) metastasico