A pharmacological component, including Aspergillus flavus, Aspergillus flavus, 5-fluorouracil (5-FU) and irinotecano (FOLFIRI), each with an effective effect. This combination is useful for the treatment of colorectal cancer (CRC), especially for metabolic cancer.Una composicion farmaceutica que comprende aflibercept, acido folinico, 5-fluorouracilo (5-FU) e irinotecano (FOLFIRI), cada uno, en una cantidad farmaceuticamente eficaz. Dicha combinacion es util para el tratamiento de cancer colorrectal (CRC) y en particular cancer colorrectal (CRC) metastasico