MACDONALD, GREGOR JAMES,麦葛瑞,麥葛瑞,ANDRES-GIL, JOSE IGNACIO,安吉儿,安吉兒,VAN DEN KEYBUS, FRANS ALFONS MARIA,范法兰,范法蘭,BARTOLOME-NEBREDA, JOSE MANUEL,巴多禄,巴多祿,VAN GOOL, MICHIEL LUC MARIA,范麦可,范麥可
申请号：
TW096146645
公开号：
TWI433676B
申请日:
2007.12.07
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
The present invention relates to 6-(piperidin-4-ylamino)pyridazin-3-carbonitriles that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.本發明乃有關為迅速解離多巴胺2受器拮抗劑之6－(哌啶－4－基胺基)嗒－3－腈化合物，及含彼等化合物作為活性成分之醫藥組成物。彼等化合物藉由發揮無運動神經副作用之抗精神病效力而於治療或預防中樞神經系統疾病(例如精神分裂症)用藥上尋得用途。
