MACDONALD, GREGOR, JAMES,ANDRES-GIL, JOSE, IGNACIO,VAN DEN KEYBUS, FRANS, ALFONS, MARIA,BARTOLOME-NEBREDA, JOSE MANUEL,VAN GOOL, MICHIEL, LUC, MARIA
申请号：
HK10101123.6
公开号：
HK1137434B
申请日:
2010.02.02
申请国别(地区):
HK
年份:
2014
代理人:
摘要：
The present invention relates to 6-(piperidin-4-ylamino)pyridazin-3-carbonitriles of the general formula (I)； or a pharmaceutically acceptable salt thereof, or a stereoisomeric form, that are fast dissociating dopamine 2 receptor antagonists, as well as processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.
