The Board of Trustees of the Leland Stanford Junior University
发明人:
Yun-Sheng CHEN,Sanjiv S. GAMBHIR
申请号：
US16831899
公开号：
US20200323999A1
申请日:
2020.03.27
申请国别(地区):
US
年份:
2020
代理人:
摘要：
A nanodroplet particle useful as an imaging contrast agent comprises a saline solution that upon irradiation with a radiofrequency energy generate a detectable acoustic signal. The saline solution nanodroplets can be encapsulated by a fluorinated shell that maintains the integrity of the nanodroplets. The saline solution and the fluorinated shell form the nanoparticles when sonicated, for example, in the presence of a non-ionic surfactant to form double-emulsion compositions. The nanoparticles of the disclosure may be advantageously useful as imaging contrast agents suitable for providing a detectable signal when administered to an animal or human subject. The nanoparticles can be conjugated to targeting agents such as biomarker or cell-specific ligands so that the nanoparticles may be concentrated to a desired target such as, but not limited to, a suspected tumor.
