PURPOSE: A cosmetic composition containing calluses or a culture containing the calluses is provided to improve skin whitening or anti-wrinkling effect. CONSTITUTION: A cosmetic composition contains a culture containing calluses which are cultured in a medium containing useful substances for culturing or the calluses acquired from the culture as an active ingredient. The calluses are derived from Trigonotis peduncularis, Phaseolus angularis, or Sophora japonica. A method for manufacturing the cosmetic composition comprises the steps of: inducing calluses from a plant seed in the medium containing the useful substances and culturing the calluses; and producing the cosmetic composition containing the calluses or the culture containing the calluses. The useful substances are quercetin, silymarin, lipoic acid, or a mixture thereof. The plant is Trigonotis peduncularis, Phaseoli semen, or Sophora japonica. [Reference numerals] (AA) Callus obtained from Trigonotis peduncularis or a culture containing the callus (example); (BB) Callus obtained from Trigonotis peduncularis or a culture containing the callus (comparative example); (CC) Callus obtained from Phaseolus angularis or a culture containing the callus (example); (DD) Callus obtained from Phaseolus angularis or a culture containing the callus (comparative example); (EE) Callus obtained from Sophora japonica or a culture containing the callus (example); (FF) Callus obtained from Sophora japonica or a culture containing the callus (comparative example)본 발명은 캘러스 또는 캘러스를 포함하는 배양물을 함유하는 화장료 조성물에 관한 것이다. 보다 구체적으로, 본 발명은 배양 유용 물질을 포함하는 배지에서 배양된 캘러스를 포함하는 배양물 또는 상기 배양물로부터 얻은 캘러스를 유효성분으로 포함하는 화장료 조성물에 관한 것이다.