PROBLEM TO BE SOLVED: To provide an anticancer drug effect enhancer which enhances the therapeutic effect by the administration of anticancer drugs in the anticancer drug-resistant carcinoma or cases.SOLUTION: The anticancer drug effect enhancer contains an aldo-keto reductase 1C family (AKR1C) inhibitor such as mefenamic acid, and the enhancer can be administered in combination with an anticancer drug such as cisplatin or fluorouracil to reduce the amount of the anticancer drug administered to a patient to whom the administration of the anticancer drug such as cisplatin or fluorouracil is effective but shows critical side effects and reduce the side effects.COPYRIGHT: (C)2011,JPO&INPIT【課題】抗癌剤耐性の癌腫または症例において、抗癌剤投与による治療効果を増強させる抗癌剤効果増強剤の提供。【解決手段】メフィナム酸の如きアルドケト還元酵素1Cファミリー(AKR1C)阻害剤をシスプラチン又はフルオロウラシル如き抗癌剤と併用投与して、シスプラチンやフルオロウラシル等の抗癌剤投与効果があるものの副作用が重篤である患者に対して、抗癌剤の投与量を低減することができ、副作用を軽減することができる抗癌剤効果増強剤。【選択図】なし
