SHEPARD, Harold, Michael,THOMPSON, Curtis,LI, Xiaoming,FROST, Gregory, Ian
申请号：
DK11735755
公开号：
DK2595624T3
申请日:
2011.07.15
申请国别(地区):
DK
年份:
2018
代理人:
摘要：
Provided herein are methods for ameliorating an adverse effect of systemic administration of a PEG hyaluronan degrading enzyme to a subject. The methods involve systemically administering a PEGylated hyaluronan degrading enzyme, particularly a PEGylated hyaluronidase, such as any of the animal or bacterial hyaluronidases, to the subject and administering an amount of a corticosteroid sufficient to ameliorate the adverse effect. Also provided are method of treating a hyaluronan-associated disease or condition for single-agent therapy or combination therapy.
