Pierfausto Seneci,Laura Belvisi,Federica Cossu,Domenico Delia,Carmelo Drago,Daniele Lecis,Stefano Maiorana,Leonardo Pierpaolo Manzoni,Eloise Mastrangelo,Mario Milani de Mayo de Mari,Paola Maria Chiara
申请号：
US14379675
公开号：
US20150119342A1
申请日:
2012.02.20
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to conformationally constrained homo- and heterodimeric mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients.
