Pierfausto Seneci,Laura Belvisi,Federica Cossu,Domenico Delia,Carmelo Drago,Daniele Lecis,Stefano Maiorana,Leonardo Pierpaolo Manzoni,Eloise Mastrangelo,Mario Milani de Mayo de Mari,Paola Maria Chiara
申请号：
US15071677
公开号：
US09730976B2
申请日:
2016.03.16
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to conformationally constrained homo- and heterodimeric mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients.
