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Improved persistent infection Sendai virus vector
专利权人:
独立行政法人産業技術総合研究所
发明人:
西村 健,瀬川 宏知,中西 真人
申请号:
JP2009510838
公开号:
JP4936482B2
申请日:
2008.04.11
申请国别(地区):
JP
年份:
2012
代理人:
摘要:
A persistently infective virus vector is produced by using a gene so modified as to encode an amino acid sequence including a valine substituted for an amino acid residue at position-1618 in the amino acid sequence for an L protein of a persistently non-infective Sendai virus. A non-transmissible, persistently infective virus vector is also produced by defecting or deleting at least one of M gene, F gene, and HN gene. These virus vectors have no cytotoxicity, can achieve the sustained gene expression over a long period of time, is safe, and is therefore useful.
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中国工程科技知识中心
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