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SISTEMA DE LIBERACION TRANSDERMICO
专利权人:
LTS LOHMANN THERAPIE-SYSTEME AG
发明人:
HILLE, THOMAS,WAUER, GABRIEL,SEIBERTZ, FRANK,WEINHEIMER, SHU-LUN
申请号:
PE0025562015
公开号:
PE00022016A1
申请日:
2014.06.04
申请国别(地区):
PE
年份:
2016
代理人:
摘要:
The Invention relates to a transdermal Therapeutic System for transdermal Administration of buprenorphine, comprising a self-adhesive Layer Structure containing buprenorphine) comprising a layer of Waterproof backing to buprenorphine, and an Adhesive Layer (b) sensitive to p Resion containing buprenorphine on this layer of Waterproof backing to buprenorphine,The Adhesive Layer comprising a) at least one Pressure Sensitive Adhesive base Polymer, (b) an effective amount of buprenorphine analgesicamente base or a pharmaceutically acceptable Salt thereof, (c) a substance that increases the viscosity in an amount of about 0.1% to around Around 8% of the Pressure Sensitive Adhesive Layer containing buprenorphine,And (d) a carboxylic acid selected from the group consisting of oleic acid, linoleic acid, Linolenic Acid, levulinic acid, and mixtures thereof,In sufficient quantity for the actual amount of buprenorphine is Solubilized in the analgesicamente to form a mixture including the substance that increases the viscosity and the mixture containing buprenorphine - carboxylic acid - and substance that increases the viscosity of Positos dispersed in said Pressure Sensitive adhesive.And where the Pressure Sensitive Adhesive Layer containing buprenorphine is the layer in contact with the skinLa invencion se relaciona con sistema terapeutico transdermico para la administracion transdermica de buprenorfina, comprendiendo una estructura de capa auto-adhesiva conteniendo buprenorfina comprendiendo A) una capa de respaldo impermeable a la buprenorfina, y B) una capa adhesiva sensible a la presion conteniendo buprenorfina sobre dicha capa de respaldo impermeable a la buprenorfina, la capa adhesiva comprendiendo a) al menos un adhesivo sensible a la presion de base polimerica, b) una cantidad efectiva analgesicamente de base de buprenorfina o una sal farmaceuticamente aceptable de la misma, c) una sustancia que aumenta la viscosidad en una cantidad de alrededor de 0,1% a alrededor de
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